Normal tissue complications after radiation therapy

Normal tissue complications after radiation therapy.

This paper describes the biological mechanisms of normal tissue reactions after radiation therapy, with reference to conventional treatments, new treatments, and treatments in developing countries. It also describes biological reasons for the latency period before tissue complications arise, the relationship of dose to incidence, the effect of increasing the size of the irradiated volume, early...

Treatment of radiation-induced normal tissue lesions

Pelvic normal tissue contouring guidelines for radiation therapy: a Radiation Therapy Oncology Group consensus panel atlas.

PURPOSE To define a male and female pelvic normal tissue contouring atlas for Radiation Therapy Oncology Group (RTOG) trials. METHODS AND MATERIALS One male pelvis computed tomography (CT) data set and one female pelvis CT data set were shared via the Image-Guided Therapy QA Center. A total of 16 radiation oncologists participated. The following organs at risk were contoured in both CT sets: ...

Can the Severity of Normal Tissue Damage after Radiation Therapy Be Predicted?

R adiotherapy can lead to both acute and late side effects, the former occurring over a timescale of weeks and then subsiding. Late effects occur months or even years after cessation of treatment and often show continuous progression with time. With conventionally fractionated radiotherapy, the late side effects usually limit the dose. There are clear differences between patients regarding side...

Normal tissue toxicity after small field hypofractionated stereotactic body radiation

Stereotactic body radiation (SBRT) is an emerging tool in radiation oncology in which the targeting accuracy is improved via the detection and processing of a three-dimensional coordinate system that is aligned to the target. With improved targeting accuracy, SBRT allows for the minimization of normal tissue volume exposed to high radiation dose as well as the escalation of fractional dose deli...